Cameron D R, Muller M J, Faoagali J
Royal Brisbane Hospital, Herston, Queensland, Australia.
Burns. 1998 Aug;24(5):475-7. doi: 10.1016/s0305-4179(98)00058-8.
The effect of burns surgery that requires intraoperative transfusion of five or more units of blood on serum vancomycin levels was assessed.
Serum vancomycin levels were measured 10 min and 6 h after vancomycin administration with surgery being performed in the interval. The following day the same dose of vancomycin was given and serum vancomycin levels measured at the same times without intervening surgery.
Thirteen operations involving nine patients who required a mean blood transfusion of 9.2 units were studied. There was very little difference between 10-min levels, 6-h levels and the change over interval (absolute and percentage) on the day of surgery and the following day. The recorded serum levels were often at the lower end of the desired range, especially in patients who underwent the larger operations. This was the case on both day of surgery and the control day.
Large volume blood loss and replacement during burns surgery did not significantly affect perioperative vancomycin levels. 1998 Elsevier Science Ltd for ISBI.
评估了术中需要输注五单位及以上血液的烧伤手术对血清万古霉素水平的影响。
在万古霉素给药后10分钟和6小时测量血清万古霉素水平，在此期间进行手术。次日给予相同剂量的万古霉素，并在相同时间测量血清万古霉素水平，期间无干预手术。
对涉及9名患者的13台手术进行了研究，这些患者平均输血9.2单位。手术当天和次日的10分钟水平、6小时水平以及间隔期的变化（绝对值和百分比）之间差异很小。记录的血清水平通常处于所需范围的下限，尤其是在接受较大手术的患者中。手术当天和对照日都是如此。
烧伤手术期间大量失血和输血对围手术期万古霉素水平没有显著影响。1998年爱思唯尔科学有限公司代表国际烧伤学会出版。
