Adam A, Van Cantfort J, Gielen J
Lipids. 1976 Aug;11(8):610-5. doi: 10.1007/BF02532874.
Resorption and metabolism of cholesterol administered intraperitoneally and per os have been described in the rat utilizing a technique of double isotopic labeling. Depending upon the route of administration, these parameter vary to a large degree. Alimentary cholesterol is progressively resorbed over a period of 10 hr, while the maximal blood level of cholesterol is attained after the 6th hr following intraperitoneal injection. On the other hand, cholesterol administered per os is more rapidly utilized in biliary acid synthesis than cholesterol administered intraperitoneally. In the range of concentrations utilized in this work (10-300 mug and 0.2-300 mug, respectively, administered to the rat, orally and intraperitoneally), the rate of cholesterol resorption remained constant.
利用双同位素标记技术，已在大鼠中描述了经腹腔内和经口给予胆固醇后的吸收和代谢情况。根据给药途径，这些参数有很大差异。食物中的胆固醇在10小时内逐渐被吸收，而腹腔注射后第6小时达到胆固醇的最高血药浓度。另一方面，经口给予的胆固醇比腹腔注射的胆固醇在胆汁酸合成中更快被利用。在本研究中使用的浓度范围内（分别以10 - 300微克和0.2 - 300微克经口和腹腔内给予大鼠），胆固醇的吸收速率保持恒定。
