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Biliary excretion of diazepam in rats: influence of the route of administration and dosage.

作者信息

Phillips R, Plaa G L

出版信息

Arch Int Pharmacodyn Ther. 1981;253(2):180-91.

PMID:7325758
Abstract

The biliary excretion of diazepam metabolites was found in rats. Equivalent dosages of diazepam were administered orally and intraperitoneally. The biliary excretion was dose-dependent and was greater following intraperitoneal administration. After intravenous administration, a greater percentage of the diazepam dosage administered was excreted into the bile. Repetitive intravenous administrations yielded results which approached those observed after intraperitoneally administered dosages given as a bolus.

摘要

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