Hadjipavlou A G, Simmons J W, Yang J P, Bi L X, Simmons D J, Necessary J T
Department of Orthopaedics and Rehabilitation, The University of Texas Medical Branch, Galveston 77555-0792, USA.
J Spinal Disord. 1998 Aug;11(4):318-21.
The mechanism mediating the chronic pain associated with lumbar disc degeneration may involve neurotransmitters elaborated by dorsal root ganglion (DRG). This hypothesis has been tested in an applicable rabbit model of disc degeneration. Twenty control male rabbits underwent a soft-tissue release; 20 experimental rabbits sustained a facetectomy and capsulotomy and received an acute torsional lumbar injury. The levels of calcitonin gene-related peptide, vasoactive intestinal peptide, and substance P were measured in the DRG, spinal cord, and disc at 10, 30, 60, and 90 days postoperatively. Torsional injury was associated with a statistically significant increase in most DRG and spinal cord neurotransmitter values after 60-90 days. These points in time marked the periods of maximum biomechanical instability and disc narrowing. Such data support concepts about the association between chronic lumbar spinal instability, disc degeneration, and pain.
介导与腰椎间盘退变相关的慢性疼痛的机制可能涉及背根神经节（DRG）产生的神经递质。这一假说已在适用的椎间盘退变兔模型中得到验证。20只对照雄兔接受软组织松解术；20只实验兔接受小关节切除术和关节囊切开术，并遭受急性腰部扭转损伤。在术后10天、30天、60天和90天测量DRG、脊髓和椎间盘内降钙素基因相关肽、血管活性肠肽和P物质的水平。扭转损伤在术后60 - 90天与大多数DRG和脊髓神经递质值的统计学显著增加相关。这些时间点标志着最大生物力学不稳定和椎间盘狭窄的时期。这些数据支持了关于慢性腰椎不稳、椎间盘退变和疼痛之间关联的概念。
