Hadjipavlou A G, Simmons J W, Yang J P, Bi L X, Ansari G A, Kaphalia B S, Simmons D J, Nicodemus C L, Necessary J T, Lane R, Esch O
Department of Orthopaedics and Rehabilitation, The University of Texas Medical Branch, Galveston 77555-0792, USA.
J Spinal Disord. 1998 Aug;11(4):312-7.
Torsional injuries may be a precursor to intervertebral disc degeneration, but published rabbit models indicate a latent time of 6 months. We describe a rabbit model in which instability and disc degeneration appear within 3 months. Sixty-five male New Zealand rabbits underwent presurgical irradiation to inhibit heterotopic bone formation. Control animals then underwent either a soft-tissue release or facetectomy and capsulotomy, whereas experimental animals received surgery and an acute 30 degrees torsional lumbar injury. Capsulotomy, as well as facetectomy without torsion, failed to effect disc degeneration. However, the rabbits that received torsion exhibited clear indications of degenerative disc changes (thinning, increased PLA2 levels, and decreased nucleus pulposus volume) within 60-90 days. The observations associate disc degeneration with a destabilizing acute torsional injury.
扭转损伤可能是椎间盘退变的先兆，但已发表的兔模型显示潜伏期为6个月。我们描述了一种兔模型，其中不稳定和椎间盘退变在3个月内出现。65只雄性新西兰兔接受术前照射以抑制异位骨形成。然后，对照动物接受软组织松解或小关节切除术和关节囊切开术，而实验动物接受手术并伴有急性30度腰椎扭转损伤。关节囊切开术以及无扭转的小关节切除术均未导致椎间盘退变。然而，遭受扭转的兔子在60 - 90天内出现了椎间盘退变的明显迹象（变薄、磷脂酶A2水平升高和髓核体积减小）。这些观察结果将椎间盘退变与不稳定的急性扭转损伤联系起来。
