Spillantini M G, Crowther R A, Jakes R, Cairns N J, Lantos P L, Goedert M
MRC Centre for Brain Repair and Department of Neurology, University of Cambridge, UK.
Neurosci Lett. 1998 Jul 31;251(3):205-8. doi: 10.1016/s0304-3940(98)00504-7.
Alpha-synuclein forms the major component of Lewy bodies and Lewy neurites, the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies. Here we show that alpha-synuclein is also the major component of the filamentous inclusions of multiple system atrophy which comprises several neurodegenerative diseases with a shared filamentous pathology in nerve cells and glial cells. These findings provide an unexpected link between multiple system atrophy and Lewy body disorders and establish that alpha-synucleinopathies constitute a major class of human neurodegenerative disorder.
α-突触核蛋白是路易小体和路易神经突的主要成分，这是帕金森病和路易体痴呆的典型神经病理学特征。我们在此表明，α-突触核蛋白也是多系统萎缩的丝状包涵体的主要成分，多系统萎缩包括几种神经退行性疾病，在神经细胞和胶质细胞中具有共同的丝状病理学特征。这些发现揭示了多系统萎缩与路易体疾病之间出人意料的联系，并确定α-突触核蛋白病构成了人类神经退行性疾病的一大类。
