Abruzzo T, Shengelaia G G, Dawson R C, Owens D S, Cawley C M, Gravanis M B
Department Radiology, Emory University School of Medicine, Atlanta, GA 30322, USA.
AJNR Am J Neuroradiol. 1998 Aug;19(7):1309-14.
Vein pouch aneurysms are the most commonly created experimental lesions in neuroendovascular research. We sought to determine whether an experimental aneurysm that is derived from a pancreatic elastase-digested arterial sac (EDASA) models the histology and morphology of human cerebral aneurysms more accurately than the vein pouch aneurysm does.
EDASAs were created in the common carotid arteries of four rabbits, and vein pouch aneurysms were created in the common carotid arteries of four pigs. Five recently ruptured human cerebral aneurysms were obtained at autopsy. Identical histologic preparations were made for all specimens, and a vascular pathologist performed blinded histologic analyses. Morphologic dimensions were measured with a micrometer at 40-fold magnification.
In each human cerebral aneurysm, there was complete absence of internal elastic lamina and tunica media, and none showed evidence of mural inflammation or neointimal proliferation. Average wall thickness was 51 microm. All vein pouch aneurysms had a well-developed internal elastic lamina and tunica media, and all exhibited profound inflammation and neointimal proliferation. Average wall thickness was 290 microm. EDASAs were devoid of internal elastic lamina, their tunica medias were mildly atrophic, and the sac walls contained only mild inflammation and neointimal proliferation. Average wall thickness was 46 microm.
EDASAs model the morphologic and histologic characteristics of human cerebral aneurysms more accurately than vein pouch aneurysms do.
静脉袋状动脉瘤是神经血管内研究中最常制造的实验性病变。我们试图确定源自胰腺弹性蛋白酶消化动脉囊（EDASA）的实验性动脉瘤是否比静脉袋状动脉瘤更准确地模拟人类脑动脉瘤的组织学和形态学。
在4只兔子的颈总动脉中制造EDASA，在4头猪的颈总动脉中制造静脉袋状动脉瘤。在尸检时获取5个近期破裂的人类脑动脉瘤。对所有标本制作相同的组织学标本，由一名血管病理学家进行盲法组织学分析。在40倍放大倍数下用测微计测量形态学尺寸。
在每个人类脑动脉瘤中，均完全缺乏内弹性膜和中膜，且均未显示壁层炎症或新生内膜增生的证据。平均壁厚为51微米。所有静脉袋状动脉瘤均有发育良好的内弹性膜和中膜，且均表现出严重的炎症和新生内膜增生。平均壁厚为290微米。EDASA缺乏内弹性膜，其内膜轻度萎缩，囊壁仅含有轻度炎症和新生内膜增生。平均壁厚为46微米。
EDASA比静脉袋状动脉瘤更准确地模拟人类脑动脉瘤的形态学和组织学特征。
