Waterston J A, Halmagyi G M
Department of Neurology, Alfred Hospital, Melbourne, Australia.
Acta Otolaryngol. 1998 Jul;118(4):474-8. doi: 10.1080/00016489850154586.
Systemic gentamicin can cause acute bilateral, simultaneous, symmetrical loss of vestibular function manifested by symptoms and signs of chronic vestibular insufficiency (ataxia and oscillopsia). We report 6 patients presenting with ataxia and oscillopsia, but without a history of vertigo, who had severe unilateral loss of vestibular function on caloric testing. The absence of vertigo in these patients could be explained by two possible mechanisms: either, the unilateral loss of vestibular function was subacute, occurring over several days so that compensation could occur, or bilateral vestibular loss occurred which was then followed by asymmetrical recovery of vestibular function. The second hypothesis is supported by the observation that vestibular hair cells can regenerate after aminoglycoside damage.
全身性庆大霉素可导致急性双侧同时对称的前庭功能丧失，表现为慢性前庭功能不全的症状和体征（共济失调和视振荡）。我们报告了6例出现共济失调和视振荡但无眩晕病史的患者，他们在冷热试验中存在严重的单侧前庭功能丧失。这些患者没有眩晕可通过两种可能机制来解释：要么，单侧前庭功能丧失是亚急性的，在数天内发生，从而能够进行代偿；要么发生了双侧前庭丧失，随后前庭功能出现不对称恢复。第二个假设得到以下观察结果的支持，即氨基糖苷类药物损伤后前庭毛细胞可以再生。
