Dusinović S, Mijalković D, Saicić Z S, Durić J, Zunić Z, Niketić V, Spasić M B
Urgent Medical Aid, Belgrade, Yugoslavia.
J Environ Pathol Toxicol Oncol. 1998;17(3-4):281-4.
The activity of glutathione peroxidase (GSH-Px) as well as the activities of other antioxidative enzymes such as CuZn superoxide dismutase (CuZn SOD), catalase (CAT), glutathione reductase (GR) in erythrocytes, the plasma activity of glutathione-S-transferase (GST), and the plasma levels of vitamin E and vitamin C were evaluated in nine patients with acute myocardial infarction (AMI). Blood samples were taken before and 1, 3, 6, and 24 hours after the institution of thrombolytic therapy. The results were compared with those in 30 healthy volunteers. A significant decrease in catalase (CAT) activity and vitamin E content in patients before and after thrombolytic therapy as compared with controls was recorded. Our results confirmed that a disturbed oxidative/antioxidative balance is present after AMI and after thrombolytic therapy.
对9例急性心肌梗死（AMI）患者的红细胞中谷胱甘肽过氧化物酶（GSH-Px）活性以及其他抗氧化酶如铜锌超氧化物歧化酶（CuZn SOD）、过氧化氢酶（CAT）、谷胱甘肽还原酶（GR）的活性、血浆中谷胱甘肽-S-转移酶（GST）的活性以及维生素E和维生素C的血浆水平进行了评估。在溶栓治疗开始前以及治疗后1、3、6和24小时采集血样。将结果与30名健康志愿者的结果进行比较。记录到与对照组相比，患者在溶栓治疗前后过氧化氢酶（CAT）活性和维生素E含量显著降低。我们的结果证实，急性心肌梗死后和溶栓治疗后存在氧化/抗氧化平衡紊乱。
