Apostolski S, Marinković Z, Nikolić A, Blagojević D, Spasić M B, Michelson A M
Institute of Neurology, School of Medicine, University of Belgrade, Yugoslavia.
J Environ Pathol Toxicol Oncol. 1998;17(3-4):325-9.
The activity of glutathione peroxidase (GSH-Px) as well as the activities of other antioxidative enzymes: CuZn superoxide dismutase (CuZn SOD), catalase (CAT), glutathione reductase (GR) in erythrocytes, as well as the activity of plasma glutathione transferase (GST), and the plasma content of vitamins E and C were evaluated in 35 sporadic amyotrophic lateral sclerosis (sALS) patients. The results revealed significantly decreased activity of both GSH-Px and CuZn SOD in sALS patients compared with the control. These data showed that a disturbed oxidative/antioxidative balance in sALS patients exists not only in motoneurons but also in the blood. The effect of exogenously administered selenium (Se), antioxidants, amino acids, a Ca2+ channel blocker such as nimodipine, and their combination in Alsamin was evaluated by screening parameter levels after 9 weeks of treatment. Only the use of all components together enhanced the activity of GSH-Px and the amount of vitamin E in sALS patients. Judging by the results of clinical trials, this treatment slowed the course of the disease.
对35例散发性肌萎缩侧索硬化症（sALS）患者的红细胞中谷胱甘肽过氧化物酶（GSH-Px）以及其他抗氧化酶：铜锌超氧化物歧化酶（CuZn SOD）、过氧化氢酶（CAT）、谷胱甘肽还原酶（GR）的活性，血浆谷胱甘肽转移酶（GST）的活性，以及血浆中维生素E和C的含量进行了评估。结果显示，与对照组相比，sALS患者的GSH-Px和CuZn SOD活性均显著降低。这些数据表明，sALS患者不仅运动神经元中存在氧化/抗氧化平衡紊乱，血液中也存在这种情况。通过治疗9周后筛选参数水平，评估了外源性给予硒（Se）、抗氧化剂、氨基酸、钙通道阻滞剂如尼莫地平和它们在Alsamin中的组合的效果。只有同时使用所有成分才能提高sALS患者的GSH-Px活性和维生素E含量。从临床试验结果来看，这种治疗减缓了疾病的进程。
