Calabresi P A, Tranquill L R, McFarland H F, Cowan E P
Department of Neurology, Rhode Island Hospital-Brown University, Providence 02903, USA.
J Neuroimmunol. 1998 Aug 14;89(1-2):198-205. doi: 10.1016/s0165-5728(98)00139-8.
Cytokines are produced by numerous cell types in the peripheral blood and central nervous system (CNS), and have been implicated in the immunopathogenesis of multiple sclerosis (MS). We examined the relationship between cytokine gene expression of cerebrospinal fluid (CSF) derived cells from MS patients and disease activity as measured by contrast enhanced MRI. There was a significant correlation between the number of CSF cells and the number of contrast enhancing MRI lesions. Cytokine gene expression of TNF-alpha, IFN-gamma, and IL-10 was routinely seen, but IL-4 expression was absent except in two clinically quiescent patients. Trends were observed toward decreased TNF-alpha expression, but increased IL-10 expression, after treatment with IFN-beta1b.
细胞因子由外周血和中枢神经系统（CNS）中的多种细胞类型产生，并与多发性硬化症（MS）的免疫发病机制有关。我们研究了来自MS患者的脑脊液（CSF）衍生细胞的细胞因子基因表达与通过对比增强MRI测量的疾病活动之间的关系。CSF细胞数量与对比增强MRI病变数量之间存在显著相关性。TNF-α、IFN-γ和IL-10的细胞因子基因表达常见，但除两名临床静止患者外，未观察到IL-4表达。在用β-1b干扰素治疗后，观察到TNF-α表达有下降趋势，但IL-10表达有增加趋势。
