Chen Y, Ludescher R D, Montville T J
Department of Food Science, Cook College, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA.
Appl Environ Microbiol. 1998 Sep;64(9):3530-2. doi: 10.1128/AEM.64.9.3530-3532.1998.
Pediocin PA-1 bound to anionic lipid vesicles with saturated or unsaturated fatty acid chains in a lipid concentration-dependent fashion. Little change in binding parameters was observed for zwitterionic lipid vesicles. Decreasing the anionic lipid content of the vesicles gave a higher relative dissociation constant for the peptide-lipid interactions and further supports the electrostatic interaction model of binding.
植物乳杆菌素PA-1以脂质浓度依赖的方式与具有饱和或不饱和脂肪酸链的阴离子脂质囊泡结合。对于两性离子脂质囊泡,结合参数几乎没有变化。降低囊泡的阴离子脂质含量会使肽-脂质相互作用的相对解离常数更高,这进一步支持了结合的静电相互作用模型。