Ferson M J, Robertson P W, Donovan J W
Public Health Unit, South Eastern Sydney Area Health Service, Zetland, New South Wales, Australia.
J Paediatr Child Health. 1998 Aug;34(4):339-41. doi: 10.1046/j.1440-1754.1998.00259.x.
To estimate the proportion of 1-4-year-old New South Wales children immune to measles and compare the documented immunization history with serologically defined immune status.
Population based seroprevalence survey piggybacked onto the National Survey of Lead in Children. Immune status was determined by two different enzyme immunoassays on plasma samples from subjects.
New South Wales, February-March 1995.
Documented measles immunization collected by interview survey and serologically defined immunity.
Of 689 survey subjects, 430 (62.4%) provided a blood sample. Adequate plasma remained for both assays for 347 children, of whom 279 (80.4%) were immune by both assays. Parents of 330 stated that their children were immunised, of whom 211 (63.9%) were able to produce corroborating records. Of these 211 subjects, 178 (84.4%) were immune compared to 87 (76.3%) of 114 without records (P = 0.07).
We estimate the prevalence of true measles immunity in 1-4-year-old NSW children to be only 80%, a level inadequate to prevent outbreaks of measles in urban populations. Both long term and immediate strategies are required to increase the prevalence of immunity among NSW children; these may include lowering the age of the routine second measles dose and mounting a mass measles immunisation campaign to include preschool aged children.
评估新南威尔士州1至4岁儿童中对麻疹具有免疫力的比例，并将记录的免疫史与血清学定义的免疫状态进行比较。
基于人群的血清流行率调查，搭载于全国儿童铅含量调查之上。通过对受试者血浆样本进行两种不同的酶免疫测定来确定免疫状态。
新南威尔士州，1995年2月至3月。
通过访谈调查收集的记录在案的麻疹免疫情况以及血清学定义的免疫力。
在689名调查对象中，430名（62.4%）提供了血样。347名儿童的血浆足以进行两种检测，其中279名（80.4%）在两种检测中均显示具有免疫力。330名儿童的家长表示他们的孩子已接种疫苗，其中211名（63.9%）能够提供佐证记录。在这211名对象中，178名（84.4%）具有免疫力，而在114名无记录的儿童中，有87名（76.3%）具有免疫力（P = 0.07）。
我们估计新南威尔士州1至4岁儿童中真正具有麻疹免疫力的比例仅为80%，这一水平不足以预防城市人群中麻疹的爆发。需要长期和短期策略来提高新南威尔士州儿童的免疫率；这些策略可能包括降低常规第二剂麻疹疫苗的接种年龄，并开展大规模麻疹免疫运动以涵盖学龄前儿童。
