Kearsley J H, Fang Z M, Clarke R A
Division of Cancer Services, St George Hospital, Kogarah, New South Wales, Australia.
Australas Radiol. 1998 Aug;42(3):219-21. doi: 10.1111/j.1440-1673.1998.tb00497.x.
Severe acute toxicity to radiotherapy (radiohypersensitivity) can limit the effective use of radiotherapy and it is not usually possible to identify such individuals before treatment commences. Five patients with acute radiohypersensitivity (RH) were detected over a 3-year period. All five RH subjects demonstrated a significantly higher degree of radiation-induced chromosomal aberrations (ICA) in fresh blood lymphocytes when compared to normal controls. Results indicate the feasibility of using the ICA assay in conjunction with other tests to screen for radiosensitivity.
放疗的严重急性毒性（放射超敏反应）会限制放疗的有效应用，而且在治疗开始前通常无法识别这类个体。在3年期间检测到5例急性放射超敏反应（RH）患者。与正常对照相比，所有5例RH受试者新鲜血液淋巴细胞中的辐射诱导染色体畸变（ICA）程度均显著更高。结果表明，将ICA检测与其他检测相结合用于筛查放射敏感性是可行的。
