伴有或不伴有慢性肝病的门静脉高压患者的肺功能异常

Pulmonary function abnormality in patients with portal hypertension with or without chronic liver disease.

作者信息

Behera D, Singh M, Chawla Y, Dilawari J B

机构信息

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh.

出版信息

Indian J Chest Dis Allied Sci. 1998 Jan-Mar;40(1):33-9.

PMID:9727281

Abstract

Pulmonary function (FVC, FEV1, PEFR, MMEF) and arterial blood gases (ABG) were analysed in 30 patients of portal hypertension. The aetiology of portal hypertension included cirrhosis of liver (n = 10), non cirrhotic portal fibrosis (NCPF, n = 10) and extrahepatic portal vein obstruction (EHPVO). Ten patients with chronic active hepatitis (CAH) without portal hypertension were also studied. Most pulmonary functions were abnormal (low) in portal hypertension and the most affected parameters, were FEV1, PEFR and MMEF (p < 0.05). The same was also observed in CAH, although in less number of patients. Hypoaxemia (26.7%) and wide alveolar--arterial oxygen gradient were observed most frequently in patients of portal hypertension. These patients also had a more alkaline blood pH. EHPVO patients had better lung function and arterial blood gas values. Patients with NCPF had greater impairment in pulmonary function.

摘要

对30例门静脉高压患者的肺功能（用力肺活量、第一秒用力呼气容积、呼气峰流速、最大呼气中期流速）和动脉血气进行了分析。门静脉高压的病因包括肝硬化（n = 10）、非肝硬化门静脉纤维化（NCPF，n = 10）和肝外门静脉阻塞（EHPVO）。还对10例无门静脉高压的慢性活动性肝炎（CAH）患者进行了研究。门静脉高压患者的大多数肺功能异常（降低），受影响最严重的参数是第一秒用力呼气容积、呼气峰流速和最大呼气中期流速（p < 0.05）。CAH患者中也观察到同样情况，不过患者数量较少。门静脉高压患者中最常出现低氧血症（26.7%）和较宽的肺泡 - 动脉氧梯度。这些患者的血液pH值也更偏碱性。EHPVO患者的肺功能和动脉血气值较好。NCPF患者的肺功能损害更大。