Sockanathan S, Jessell T M
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.
Cell. 1998 Aug 21;94(4):503-14. doi: 10.1016/s0092-8674(00)81591-3.
The diversification of neuronal cell types in the vertebrate central nervous system depends on inductive signals provided by local organizing cell groups of both neural and nonneural origin. The influence of signals provided by postmitotic neurons on the fate of neurons born at subsequent development stages, however, remains unclear. We provide evidence that a retinoid-mediated signal provided by one subset of early-born spinal motor neurons imposes a local variation in the number of motor neurons generated at different axial levels and also specifies the identity of a later-born subset of motor neurons. Thus, in the vertebrate central nervous system the distinct fates of late-born neurons may be acquired in response to signals provided by early-born neurons.
脊椎动物中枢神经系统中神经元细胞类型的多样化取决于神经和非神经起源的局部组织细胞群提供的诱导信号。然而，有丝分裂后神经元提供的信号对后续发育阶段产生的神经元命运的影响仍不清楚。我们提供的证据表明，早期出生的脊髓运动神经元的一个亚群提供的类视黄醇介导信号，会导致不同轴向水平产生的运动神经元数量出现局部差异，并且还能确定后期出生的运动神经元亚群的身份。因此，在脊椎动物中枢神经系统中，后期出生的神经元的不同命运可能是对早期出生的神经元提供的信号作出的反应而获得的。
