Thörn M, Pontén F, Johansson A M, Bergström R
Department of Surgery, University Hospital, Uppsala, Sweden.
Cancer Detect Prev. 1998;22(5):430-7. doi: 10.1046/j.1525-1500.1998.00052.x.
We analyzed incidence trends of cutaneous melanoma in situ in Sweden in 1968-1992. Among men, age-standardized rates increased from 0.1/100,000 in 1968 to 2.9/100,000 in 1992, which corresponds to an average annual increase of 15.0%. Among women, rates increased from 0.3 to 3.7, and the annual increase was 12.8%. Age-specific rates increased since 1978, predominantly in men aged 45 years and older, whereas in women rates increased in all ages. Multivariate analysis showed that incidence rates could be explained by both cohort effects and period effects in addition to age. However, cohort effects seemed more important among men than among women, in whom period effects dominated. Thus, factors associated with the development of melanoma in situ may differ between the sexes. Melanoma in situ is an immediate precursor of invasive melanoma, and the increased detection and surgical excision of these tumors will prevent the occurrence of invasive melanoma.
我们分析了1968 - 1992年瑞典原位皮肤黑色素瘤的发病趋势。在男性中，年龄标准化发病率从1968年的0.1/10万增至1992年的2.9/10万，年均增长15.0%。在女性中，发病率从0.3增至3.7，年增长率为12.8%。自1978年以来，各年龄组发病率均上升，主要是45岁及以上男性，而女性各年龄段发病率均上升。多变量分析表明，除年龄外，发病率还可由队列效应和时期效应解释。然而，队列效应在男性中似乎比在女性中更重要，在女性中时期效应占主导。因此，原位黑色素瘤发生发展相关因素可能存在性别差异。原位黑色素瘤是侵袭性黑色素瘤的直接前体，对这些肿瘤检测和手术切除的增加将预防侵袭性黑色素瘤的发生。
