Westin P, Bergh A
Department of Pathology, University of Umeå, Sweden.
Cancer Detect Prev. 1998;22(5):476-84.
Patients with advanced prostate cancer commonly present with disseminated disease. For these patients, androgen ablation is a first-line treatment. This mode of therapy usually has an initially palliative effect on tumor-related symptoms and slows growth, although virtually all tumors eventually relapse to an androgen-independent, more aggressively growing phenotype. However, surprisingly little is known about the actions mediating the initial palliative effect as well as the initiation of androgen-independent tumor growth. In this review, some current concepts on mechanisms of androgen ablation treatment and androgen-independent progression of prostate cancer is highlighted. Special attention is given to the involvement of apoptosis in these processes.
晚期前列腺癌患者通常表现为播散性疾病。对于这些患者，雄激素剥夺是一线治疗方法。这种治疗方式通常对肿瘤相关症状最初具有姑息作用，并减缓肿瘤生长，尽管几乎所有肿瘤最终都会复发为雄激素非依赖性、生长更具侵袭性的表型。然而，令人惊讶的是，对于介导初始姑息作用以及雄激素非依赖性肿瘤生长起始的作用了解甚少。在本综述中，重点介绍了一些关于雄激素剥夺治疗机制和前列腺癌雄激素非依赖性进展的当前概念。特别关注细胞凋亡在这些过程中的作用。
