Horn V, Buchar E, Janků I
Institute of Pharmacology, Academy of Sciences of the Czech Republic, Prague.
Physiol Res. 1997;46(4):279-83.
Kidney function changes after single-dose administration of borocaptate sodium (mercaptoundecahydro-closododecaborate, B12H11SH, BSH) were studied in rats. Changes of glomerular filtration rate (GFR) measured as 14C-inulin clearance, renal plasma flow rate (3H-p-aminohippuric acid clearance) and urine flow rate (UFR) after a slow intravenous injection of BSH (25 mg/kg b.w.) were investigated in rats under pentobarbital anaesthesia. It was found that a slow BSH injection induces a gradual decrease of renal plasma flow and glomerular filtration rate resulting in an almost constant reduction of the filtration fraction. These alterations were accompanied by a temporary increase of urine flow rate. Although a direct effect of BSH on the nephron cannot be excluded, it is suggested that the observed changes in kidney function might at least partly be mediated by disturbances in the function of the cardiovascular system following BSH injection. The role of the dianionic sulfhydryl group present in the borocaptate molecule in inducing these renal functional changes is discussed.
在大鼠中研究了单剂量注射硼卡钠（巯基十一氢-闭式十二硼酸，B12H11SH，BSH）后肾功能的变化。在戊巴比妥麻醉下的大鼠中，研究了缓慢静脉注射BSH（25mg/kg体重）后，以14C-菊粉清除率测量的肾小球滤过率（GFR）、肾血浆流量（3H-对氨基马尿酸清除率）和尿流率（UFR）的变化。发现缓慢注射BSH会导致肾血浆流量和肾小球滤过率逐渐降低，从而使滤过分数几乎持续降低。这些改变伴随着尿流率的暂时增加。虽然不能排除BSH对肾单位的直接作用，但提示观察到的肾功能变化可能至少部分是由注射BSH后心血管系统功能紊乱介导的。讨论了硼卡分子中存在的二价阴离子巯基在诱导这些肾功能变化中的作用。
