• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

巯基十一氢十二硼酸酯(硼卡酯)对不同大鼠组织巯基的体外作用。

The in vitro effect of sodium mercaptoundecahydrododecaborate (borocaptate) on sulfhydryl groups of different rat tissues.

作者信息

Buchar E, Horn V, Kameníková L, Janku I

机构信息

Institute of Pharmacology, Czech Academy of Sciences, Prague.

出版信息

Methods Find Exp Clin Pharmacol. 1994 Nov;16(9):619-22.

PMID:7746022
Abstract

The effect of borocaptate on structural protein sulfhydryl (SH) groups of different organs and kidney subcellular fractions was studied in vitro. It was shown that the binding capacity of borocaptate is not the same for different tissues and subcellular fractions. The highest binding capacity was in the liver, while kidney and brain values were significantly lower. Therefore, it appears that the same concentration of borocaptate may have different effects in various organs.

摘要

在体外研究了硼卡胺对不同器官及肾脏亚细胞组分结构蛋白巯基(SH)基团的影响。结果表明,硼卡胺对不同组织和亚细胞组分的结合能力不同。肝脏中的结合能力最高,而肾脏和大脑中的值则显著较低。因此,相同浓度的硼卡胺在不同器官中可能产生不同的效应。

相似文献

1
The in vitro effect of sodium mercaptoundecahydrododecaborate (borocaptate) on sulfhydryl groups of different rat tissues.巯基十一氢十二硼酸酯(硼卡酯)对不同大鼠组织巯基的体外作用。
Methods Find Exp Clin Pharmacol. 1994 Nov;16(9):619-22.
2
Kidney function changes in rats after single-dose administration of borocaptate sodium.大鼠单次给药硼卡钠后肾功能的变化。
Physiol Res. 1997;46(4):279-83.
3
The diuretic effect of borocaptate sodium in rats and in patients with brain tumors.硼卡钠对大鼠及脑肿瘤患者的利尿作用。
Methods Find Exp Clin Pharmacol. 1997 Oct;19(8):559-66.
4
Applicability of the 2-nitroimidazole-sodium borocaptate-10B conjugate, TX-2060, as a 10B-carrier in boron neutron capture therapy.2-硝基咪唑-硼硫醇钠-10B 共轭物 TX-2060 作为硼中子俘获疗法中 10B 载体的适用性。
Anticancer Res. 2004 Sep-Oct;24(5A):2975-83.
5
Intra-arterial administration of sodium borocaptate (BSH)/lipiodol emulsion delivers B-10 to liver tumors highly selectively for boron neutron capture therapy: experimental studies in the rat liver model.硼卡钠(BSH)/碘油乳剂经动脉给药可将硼-10高度选择性地输送至肝肿瘤,用于硼中子俘获治疗:大鼠肝脏模型的实验研究。
Int J Radiat Oncol Biol Phys. 2004 May 1;59(1):260-6. doi: 10.1016/j.ijrobp.2003.12.018.
6
Suitability of boron carriers for BNCT: accumulation of boron in malignant and normal liver cells after treatment with BPA, BSH and BA.硼载体用于硼中子俘获治疗的适用性:用双对氨基苯甲醚、硼氢化钠和硼酸治疗后硼在恶性和正常肝细胞中的蓄积
Appl Radiat Isot. 2009 Jul;67(7-8 Suppl):S105-8. doi: 10.1016/j.apradiso.2009.03.025. Epub 2009 Mar 26.
7
Biodistribution of boron in dogs with spontaneous intracranial tumors following borocaptate sodium administration.
Cancer Res. 1994 Mar 1;54(5):1259-63.
8
Combined use of sodium borocaptate and buthionine sulfoximine in boron neutron capture therapy enhanced tissue boron uptake and delayed tumor growth in a rat subcutaneous tumor model.在大鼠皮下肿瘤模型中,硼酸钠与丁硫氨酸亚砜胺联合用于硼中子俘获疗法可增强组织硼摄取并延缓肿瘤生长。
Cancer Lett. 2008 May 18;263(2):253-8. doi: 10.1016/j.canlet.2008.01.016. Epub 2008 Feb 12.
9
Boron neutron capture therapy of brain tumors: enhanced survival following intracarotid injection of either sodium borocaptate or boronophenylalanine with or without blood-brain barrier disruption.脑肿瘤的硼中子俘获疗法:经颈动脉注射硼酸钠或硼苯丙氨酸,无论有无血脑屏障破坏,均可提高生存率。
Cancer Res. 1997 Mar 15;57(6):1129-36.
10
Biodistribution of 10B in a rat liver tumor model following intra-arterial administration of sodium borocaptate (BSH)/degradable starch microspheres (DSM) emulsion.在经动脉注射硼卡钠(BSH)/可降解淀粉微球(DSM)乳剂后,10B在大鼠肝肿瘤模型中的生物分布。
Appl Radiat Isot. 2004 Nov;61(5):933-7. doi: 10.1016/j.apradiso.2004.05.014.