SL 75 102对成年和未成年大鼠的抗惊厥作用。
Anticonvulsant effect of SL 75 102 in adult and immature rats.
作者信息
Kubová H, Haugvicová R, Mares P
机构信息
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.
出版信息
Physiol Res. 1997;46(1):73-6.
PMID:9728525
Abstract
The anticonvulsant action of SL 75 102, a metabolite of Progabide, was studied in a model of pentylenetetrazol-induced motor seizures in adult and 12-day-old rats. SL 75 102 suppressed generalized tonic-clonic seizures in adult rats and restricted the tonic phase of these seizures in rat pups. SL 75 102 was less effective than Progabide. In addition, some minor differences in anticonvulsant actions of these two drugs were observed.
摘要
普罗加比的代谢产物SL 75 102的抗惊厥作用，在成年大鼠和12日龄大鼠的戊四氮诱导的运动性癫痫模型中进行了研究。SL 75 102抑制成年大鼠的全身性强直阵挛性癫痫发作，并限制幼鼠这些癫痫发作的强直期。SL 75 102的效果比普罗加比差。此外，还观察到这两种药物在抗惊厥作用方面存在一些细微差异。
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