Kumagai T, Malaty H M, Graham D Y, Hosogaya S, Misawa K, Furihata K, Ota H, Sei C, Tanaka E, Akamatsu T, Shimizu T, Kiyosawa K, Katsuyama T
Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
J Infect Dis. 1998 Sep;178(3):717-21. doi: 10.1086/515376.
Studies of the pattern of change in the epidemiology of Helicobacter pylori infection are scarce. A longitudinal cohort study consisted of 644 children and adults, and two independent cross-sectional surveys were conducted in rural Japan between 1986 and 1994. The anti-H. pylori IgG seroconversion rates were 1.1% and 1% per year for children and adults, respectively. The seroreversion rate per year was 1.8% for children and 1.5% for adults. The cohort study was confirmed by the two cross-sectional studies. H. pylori prevalence fell in all age groups in both children (odds ratio [OR] = 0.5, 95% confidence interval [CI] = 0.2-1.0, P = .05) and adults (OR = 0.4, 95% CI = 0.3-0.6, P = .001). The rate of loss of H. pylori infection was greater than the acquisition. Data regarding acquisition and loss of H. pylori infection are critical to understanding the epidemiology of the infection and to developing treatment and vaccination strategies.
关于幽门螺杆菌感染流行病学变化模式的研究很少。一项纵向队列研究包括644名儿童和成人，并于1986年至1994年在日本农村地区进行了两项独立的横断面调查。儿童和成人的抗幽门螺杆菌IgG血清转化率分别为每年1.1%和1%。儿童和成人的血清逆转率分别为每年1.8%和1.5%。两项横断面研究证实了该队列研究。儿童和成人所有年龄组的幽门螺杆菌感染率均下降（儿童：比值比[OR]=0.5，95%置信区间[CI]=0.2 - 1.0，P = 0.05；成人：OR = 0.4，95% CI = 0.3 - 0.6，P = 0.001）。幽门螺杆菌感染的丧失率大于获得率。关于幽门螺杆菌感染获得和丧失的数据对于理解该感染的流行病学以及制定治疗和疫苗接种策略至关重要。
