Rousselle J C, Callister S M, Schell R F, Lovrich S D, Jobe D A, Marks J A, Wieneke C A
Department of Infectious Diseases, Gundersen Lutheran Medical Center, University of Wisconsin-La Crosse, 54601, USA.
J Infect Dis. 1998 Sep;178(3):733-41. doi: 10.1086/515382.
Early Lyme borreliosis sera with significant titers of anti-outer surface protein C (OspC) borreliacidal antibodies were identified. Human anti-OspC borreliacidal antibodies could be either IgM or IgG. Significant concentrations of borreliacidal activity were detected after vaccination of mice with OspC. Detection of anti-OspC borreliacidal activity was dependent on surface expression of OspC by Borrelia burgdorferi isolate 50772. The ability of OspC to induce borreliacidal antibodies in vivo and after vaccination offers another possible explanation for the ability of vaccination with OspC to protect against infection with B. burgdorferi. Furthermore, detection of anti-OspC borreliacidal antibodies, especially IgM antibodies, in early Lyme borreliosis sera provides additional evidence that borreliacidal antibody detection may be useful for the serodiagnosis of early Lyme borreliosis.
已鉴定出早期莱姆病血清中具有高滴度的抗外表面蛋白C（OspC）杀疏螺旋体抗体。人抗OspC杀疏螺旋体抗体可以是IgM或IgG。用OspC对小鼠进行疫苗接种后，检测到显著浓度的杀疏螺旋体活性。抗OspC杀疏螺旋体活性的检测取决于伯氏疏螺旋体分离株50772的OspC表面表达。OspC在体内和疫苗接种后诱导杀疏螺旋体抗体的能力，为用OspC疫苗接种预防伯氏疏螺旋体感染的能力提供了另一种可能的解释。此外，在早期莱姆病血清中检测抗OspC杀疏螺旋体抗体，尤其是IgM抗体，提供了额外的证据，表明杀疏螺旋体抗体检测可能有助于早期莱姆病的血清学诊断。
