Lovrich Steven D, La Fleur Rhonda L, Jobe Dean A, Johnson Jennifer C, Asp Krista E, Schell Ronald F, Callister Steven M
Microbiology Research Laboratory, Gundersen Lutheran Medical Center, 1300 Badger Street, La Crosse, Wisconsin 54601, USA.
Clin Vaccine Immunol. 2007 May;14(5):635-7. doi: 10.1128/CVI.00431-06. Epub 2007 Mar 7.
Humans reliably produce high concentrations of borreliacidal OspC antibodies specific for the seven C-terminal amino acids shortly after infection with Borrelia burgdorferi. We show that dogs also produce OspC borreliacidal antibodies but that their frequencies, intensities, and antigenicities differ significantly. The findings therefore confirm a major difference between the borreliacidal antibody responses of humans and canines with Lyme disease.
人类在感染伯氏疏螺旋体后不久，就能可靠地产生针对七个C末端氨基酸的高浓度具有杀疏螺旋体活性的OspC抗体。我们发现狗也能产生具有杀疏螺旋体活性的OspC抗体，但其频率、强度和抗原性存在显著差异。因此，这些发现证实了人类和患莱姆病犬类的杀疏螺旋体抗体反应之间的主要差异。
