Venegas W, Zapata I, Carbonell E, Marcos R
Departamento de Biología Molecular, Facultad de Ciencias Biológicas, Universidad de Concepción, Chile.
Teratog Carcinog Mutagen. 1998;18(3):123-9.
To estimate the genetic risk associated with pesticide exposure in a defined population, the frequency of micronuclei (MN) in peripheral blood lymphocytes from a group of 22 pesticide sprayers from Concepción, Chile, occupationally exposed to pesticide mixtures was evaluated. After scoring 1,000 binucleated cells for each donor, no significant increases were observed either for the total number of MN or for binucleated cells with MN, when compared with a concurrent control population. In addition, when the effects of different confounding factors such as age, smoking, and drinking habits were considered, no significant effect was observed. Our conclusion is that, in this specific group of workers and under the particular conditions of exposure to pesticides, when evaluated by the micronucleus assay, no genetic risk was detected.
为了评估特定人群中与接触农药相关的遗传风险，对来自智利康塞普西翁的一组22名职业性接触农药混合物的农药喷洒工人外周血淋巴细胞中的微核（MN）频率进行了评估。在对每位供体的1000个双核细胞进行评分后，与同期对照人群相比，微核总数或含有微核的双核细胞数量均未观察到显著增加。此外，在考虑年龄、吸烟和饮酒习惯等不同混杂因素的影响时，也未观察到显著影响。我们的结论是，在这一特定工人群体以及在特定的农药接触条件下，通过微核试验评估时，未检测到遗传风险。
