单侧忽视中的多巴胺能刺激
Dopaminergic stimulation in unilateral neglect.
作者信息
Geminiani G, Bottini G, Sterzi R
机构信息
Department of Psychology, University of Turin, and Istituto Nazionale Neurologico C Besta, Milan, Italy.
出版信息
J Neurol Neurosurg Psychiatry. 1998 Sep;65(3):344-7. doi: 10.1136/jnnp.65.3.344.
OBJECTIVE
To explore the hypothesis that dopaminergic circuits play a part in the premotor components of the unilateral neglect syndrome, the effects of acute dopaminergic stimulation in patients with neglect were studied.
METHODS
Two tasks were evaluated before and after subcutaneous administration of apomorphine and placebo: a circle crossing test and a test of target exploration (a modified version of the bell test), performed both in perceptual (counting) and in perceptual-motor (pointing) conditions.
SUBJECTS
Four patients with left neglect.
RESULTS
After dopaminergic stimulation, a significant improvement was found compared with placebo administration and baseline evaluation, in the performance of the two tests. Three of the patients had a more marked improvement in the perceptual-motor condition (pointing) of the task than the perceptual condition (counting).
CONCLUSIONS
The findings suggest that dopaminergic neuronal networks may mediate, in different ways, both perceptive and premotor components of the unilateral neglect syndrome.
目的
为探讨多巴胺能回路在单侧忽视综合征运动前成分中发挥作用这一假说，对忽视患者进行急性多巴胺能刺激的效果展开研究。
方法
在皮下注射阿扑吗啡和安慰剂前后，对两项任务进行评估：一项是圆圈交叉试验，另一项是目标探索试验（改良版铃声试验），这两项试验均在知觉（计数）和知觉运动（指向）条件下进行。
研究对象
四名左侧忽视患者。
结果
多巴胺能刺激后，与安慰剂给药及基线评估相比，两项试验的表现均有显著改善。三名患者在任务的知觉运动条件（指向）下的改善比知觉条件（计数）下更为明显。
结论
研究结果表明，多巴胺能神经元网络可能以不同方式介导单侧忽视综合征的知觉和运动前成分。
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