Prevalence of monoclonal gammopathies in patients with hepatitis C virus infection.

BACKGROUND

An association between monoclonal gammopathies and chronic liver diseases has been reported.

OBJECTIVE

To determine the prevalence of monoclonal gammopathies in patients with chronic hepatitis C virus (HCV) infection and the possible association of monoclonal gammopathies with HCV genotypes.

DESIGN

Prospective study.

SETTING

Departments of internal medicine and hematology at two university hospitals in Italy.

PATIENTS

239 HCV-positive and 98 HCV-negative patients with chronic liver diseases were recruited consecutively.

MEASUREMENTS

Clinical data were gathered, liver histologic examination was done, serum immunoglobulin and cryoglobulin levels were measured, and immunoelectrophoresis was done for monoclonal component detection. Patients with monoclonal gammopathy had serum HCV RNA measured and HCV genotype determined by polymerase chain reaction and had histologic examination of bone marrow.

RESULTS

Monoclonal band was detected in 11% of HCV-positive patients and in 1% of HCV-negative patients (P = 0.004). The prevalence of HCV genotype 2a/c was higher in patients with monoclonal gammopathies than in those without (50% compared with 18%; P = 0.009).

CONCLUSION

The prevalence of monoclonal gammopathies in patients with HCV-related chronic liver disease is striking and is often associated with genotype 2a/c infection.