Harms-Ringdahl M
Swedish Radiation Protection Institute, S-171 16 Stockholm, Sweden.
Mutat Res. 1998 Aug 3;404(1-2):27-33. doi: 10.1016/s0027-5107(98)00091-8.
The early observations on the possible induction of transmissible genomic instability after exposure to ionising radiation has received a strong support in the literature during the last 10 years. Aided by new research tools in biology, the better understanding of the mechanisms behind genomic instability leads to conclusions which are challenging the existing views on the interaction and response of the genome to radiation or chemicals. It has become commonly accepted that the full revelation of biological pathways leading to the loss of stability of the genome will also be a major step in the understanding of carcinogenesis. In this short review, some aspects of the recent knowledge and their implications are discussed.
过去十年间，关于暴露于电离辐射后可能诱发可传播基因组不稳定性的早期观察结果在文献中得到了有力支持。借助生物学领域的新研究工具，对基因组不稳定性背后机制的更深入理解得出了一些结论，这些结论正在挑战关于基因组对辐射或化学物质的相互作用及反应的现有观点。人们普遍认为，全面揭示导致基因组稳定性丧失的生物学途径也将是理解致癌作用的重要一步。在这篇简短的综述中，将讨论近期知识的一些方面及其影响。
