Department of Radiopharmacy, Faculty of Pharmacy, Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences, Sari, 48175-861, Iran.
Drug Discov Today. 2010 Nov;15(21-22):907-18. doi: 10.1016/j.drudis.2010.09.005. Epub 2010 Oct 7.
DNA is the cellular target that has the most damage induced by ionizing radiation (IR). If genomic instability resulting from this DNA damage is not correctly repaired, it leads to mutation, cancer and cell death. Flavonoids are a family of natural products that affect oxidative stress and enhance genomic stability through DNA interaction. Although flavonoids exert protective effects against IR in normal cells, they enhance genotoxicity effects of this radiation in cancer cells, a beneficial effect that is of interest in the design of new anticancer pharmaceuticals. This review describes the molecular effects of IR on DNA structure and mechanisms by which flavonoids exert their effect on ionizing-radiation-induced genomic instability.
DNA 是电离辐射（IR）诱导损伤最严重的细胞靶标。如果这种 DNA 损伤导致的基因组不稳定性不能被正确修复，就会导致突变、癌症和细胞死亡。类黄酮是一类天然产物，可通过与 DNA 相互作用影响氧化应激和增强基因组稳定性。虽然类黄酮在正常细胞中对 IR 具有保护作用，但它们会增强癌细胞中这种辐射的遗传毒性作用，这种有益的作用在设计新型抗癌药物时引起了人们的兴趣。本文综述了 IR 对 DNA 结构的分子影响，以及类黄酮发挥其对电离辐射诱导的基因组不稳定性作用的机制。
