染色体畸变的起源机制。

Mechanisms of the origin of chromosomal aberrations.

作者信息

Palitti F

机构信息

Department of Agrobiology and Agrochemistry, University of Tuscia, Via San Camillo de Lellis, s.n., I-01100 Viterbo, Italy.

出版信息

Mutat Res. 1998 Aug 3;404(1-2):133-7. doi: 10.1016/s0027-5107(98)00106-7.

DOI:10.1016/s0027-5107(98)00106-7

PMID:9729334

Abstract

This manuscript gives a selective survey of some aspects of the origin of chromosomal aberrations (CA). The following topics are discussed: heterogeneity regarding the induction of initial DNA lesions and their repair among chromosomes or regions of the same chromosome, ratio between symmetrical and asymmetrical exchanges, influence of DNA repeats, chromatin condensation and cell-cycle checkpoints on the formation of chromosome alterations.

摘要

本手稿对染色体畸变（CA）起源的某些方面进行了选择性综述。讨论了以下主题：初始DNA损伤诱导及其在不同染色体或同一染色体不同区域间修复的异质性、对称与不对称交换的比例、DNA重复序列、染色质凝聚和细胞周期检查点对染色体改变形成的影响。