Kraemer C, Weil B, Christmann M, Schmidt E R
Institute for Molecular Genetics, Biosafety Research and Consulting, Johannes Gutenberg-University Mainz, D-55099, Mainz, Germany.
Gene. 1998 Aug 31;216(2):267-76. doi: 10.1016/s0378-1119(98)00347-3.
DmX is a novel gene from Drosophila melanogaster located on the X chromosome in region 5D5/6-E1. The molecular analysis of the genomic and cDNA sequences of DmX shows that the gene spans appr. 16kb and displays a mosaic structure with 15 exons. The 12kb long DmX transcript is present in Drosophila embryos, larvae and adults of both sexes. The open reading frame of DmX encodes a novel WD-repeat protein, containing at least 30 WD-repeat units. WD-repeat proteins contain a conserved motif of approximately 40 amino acids (aa), usually ending with the dipeptide Trp-Asp (WD). Homologues of the DmX gene exist in other dipteran species, in Caenorhabditis elegans and human, revealing that DmX is an evolutionarily well conserved gene. The inferred DMX amino acid sequence shows also limited, but significant similarity to a yeast ORF with unknown function. 1998 Elsevier Science B.V.
DmX是一种来自黑腹果蝇的新基因，位于X染色体的5D5/6 - E1区域。对DmX的基因组和cDNA序列进行分子分析表明，该基因跨度约为16kb，具有由15个外显子组成的镶嵌结构。12kb长的DmX转录本存在于果蝇胚胎、幼虫以及雌雄成虫中。DmX的开放阅读框编码一种新型WD重复蛋白，至少包含30个WD重复单元。WD重复蛋白含有一个约40个氨基酸（aa）的保守基序，通常以二肽色氨酸 - 天冬氨酸（WD）结尾。DmX基因的同源物存在于其他双翅目物种、秀丽隐杆线虫和人类中，这表明DmX是一个在进化上高度保守的基因。推断出的DMX氨基酸序列与一种功能未知的酵母开放阅读框也显示出有限但显著的相似性。1998爱思唯尔科学出版社B.V.
