不同肌醇-1,4,5-三磷酸（Ins(1,4,5)P3）受体激动剂诱发非洲爪蟾卵母细胞中基本Ca2+ 钙瞬变的动力学
Kinetics of elementary Ca2+ puffs evoked in Xenopus oocytes by different Ins(1,4,5)P3 receptor agonists.
作者信息
Marchant J S, Parker I
机构信息
Department of Pharmacology, University of Cambridge, CB2 1QJ, U.K.
出版信息
Biochem J. 1998 Sep 15;334 ( Pt 3)(Pt 3):505-9. doi: 10.1042/bj3340505.
Abstract
Elementary Ca2+ puffs form the basic building blocks of global Ins(1, 4,5)P3-evoked Ca2+ signals. In Xenopus oocytes, Ca2+ puffs evoked by the high-affinity agonist adenophostin were shorter and smaller than puffs evoked by Ins(1,4,5)P3 and the lower affinity analogue Ins(2,4, 5)P3. Agonist-specific mechanisms, therefore, play a role in shaping local Ca2+ release events, but termination of Ca2+ flux is not delimited simply by agonist dissociation.
摘要
初级Ca2+ 钙瞬变构成了全局Ins(1,4,5)P3诱发的Ca2+ 信号的基本组成部分。在非洲爪蟾卵母细胞中，高亲和力激动剂腺嘌呤核苷酸诱发的Ca2+ 钙瞬变比Ins(1,4,5)P3和低亲和力类似物Ins(2,4,5)P3诱发的钙瞬变更短、更小。因此，激动剂特异性机制在塑造局部Ca2+ 释放事件中发挥作用，但Ca2+ 通量的终止并非简单地由激动剂解离所界定。
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