Márton I, Bágyi K, Radics T, Kiss C
Debreceni Orvostudományi Egyetem, Restauratív Fogászati Tanszék.
Fogorv Sz. 1998 Aug-Sep;91(8-9):269-74.
During the last 25 years there have been major advances in understanding the etiology, pathogenesis and maintenance of inflammatory processes taking place in the periapical space. Polymicrobial infection of the pulp chamber is of primary importance in initiating periapical inflammation. Egress of bacteria and their antigenes stimulate the immune system to form a granulation tissue around the apical area. Local immune response eliminates excess number of invading organisms. However, in parallel with protective reactions, local activity of immunocompetent cells and their soluble products also contribute to tissue damage, bone resorption and perpetuation of inflammation. Present data indicate that interaction of T-lymphocytes and macrophages is crucial in this process.
在过去的25年里，人们对根尖周组织中发生的炎症过程的病因、发病机制及持续存在有了重大进展。牙髓腔的多微生物感染在引发根尖周炎中至关重要。细菌及其抗原的逸出刺激免疫系统在根尖区域周围形成肉芽组织。局部免疫反应清除过量入侵的微生物。然而，与保护反应同时，免疫活性细胞及其可溶性产物的局部活性也会导致组织损伤、骨吸收及炎症持续存在。目前的数据表明，T淋巴细胞与巨噬细胞的相互作用在这一过程中至关重要。
