Komori T, Kishimoto T
Department of Medicine III, Osaka University Medical School, Japan. Science and Technology Corporation, Japan.
Curr Opin Genet Dev. 1998 Aug;8(4):494-9. doi: 10.1016/s0959-437x(98)80123-8.
A factor fundamental to bone formation has been identified. Gene targeting shows that core-binding factor alpha 1 (Cbfa1) plays an essential role in bone formation and osteoblast differentiation. Thus, it is now possible to begin examining the molecular mechanism of bone formation--especially osteoblast differentiation.
一种对骨形成至关重要的因子已被确定。基因靶向研究表明，核心结合因子α1（Cbfa1）在骨形成和成骨细胞分化中起关键作用。因此，现在有可能开始研究骨形成——尤其是成骨细胞分化的分子机制。
