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[软组织恶性黑色素瘤(透明细胞肉瘤)——多器官定位的罕见病例]

[Malignant melanoma of soft parts (clear cell sarcoma)--a rare case of multiorgan localization].

作者信息

Kothaj P, Turcan I, Marko L, Cunderlík P, Fukal J, Okapec S

机构信息

Chirurgická klinika IVZ, Nemocnica F. D. Roosevelta, Banská Bystrica, Slovenská republika.

出版信息

Rozhl Chir. 1998 Jul;77(7):328-33.

PMID:9729915
Abstract

Malignant melanoma of soft parts (MMSP) is a rare tumor originally described by Enzinger in 1965 as clear cell sarcoma of tendons and aponeuroses because of its affinity to tenosynovial structures. Tumors are found predominantly at the extremities. First visceral case was described in 1993 in the duodenum. We describe the case of 64-years old man with malignant melanoma of soft parts in the stomach, in the pancreas, in the mesocolon, in the left thigh and in the left axilla. This patient was successfully treated surgically by the resection of the stomach, resection of the pancreatic head, extirpation of the tumor from mesocolon, from the left thigh and from the left axilla. In all these localisations the tumor was histologically and imunohistochemically proved to be MMSP (positivity: s-100 protein, vimentin, HMB-45 and negativity CK, EMA, desmin, actin). This multivisceral occurrence is extremely rare and according to the review of literature this is probably the first published case of MMSP in the stomach and in the pancreas.

摘要

软组织恶性黑色素瘤(MMSP)是一种罕见肿瘤,1965年由恩津格首次描述为肌腱和腱膜透明细胞肉瘤,因其与腱鞘滑膜结构的亲和性。肿瘤主要发生于四肢。首例内脏病例于1993年在十二指肠被描述。我们报道一例64岁男性,其胃、胰腺、结肠系膜、左大腿和左腋窝均发生软组织恶性黑色素瘤。该患者通过胃切除术、胰头切除术、从结肠系膜、左大腿和左腋窝切除肿瘤,成功接受了手术治疗。在所有这些部位,肿瘤经组织学和免疫组织化学证实为MMSP(阳性:s-100蛋白、波形蛋白、HMB-45;阴性:细胞角蛋白、上皮膜抗原、结蛋白、肌动蛋白)。这种多脏器发生极为罕见,根据文献回顾,这可能是首例发表的胃和胰腺MMSP病例。

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