心肌梗死糖尿病大鼠中心房利钠肽表达受损。

Impaired expression of atrial natriuretic peptide in diabetic rats with myocardial infarction.

作者信息

Inoue M, Kanda T, Arai M, McManus B M, Suzuki T, Kobayashi I, Nagai R

机构信息

The Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.

出版信息

Res Commun Mol Pathol Pharmacol. 1998 Jun;100(3):327-38.

PMID:9730011

Abstract

We evaluated the effects of myocardial infarction (MI) on the hemodynamics and the expression of atrial natriuretic peptide (ANP) mRNA in rats with streptozotocin-induced diabetes. Eight weeks after streptozotocin injection, the diabetic rats and age-matched nondiabetic controls underwent coronary artery ligation. One week later, the left ventricular end-diastolic pressure, systolic blood pressure, infarct size, and serum ANP levels did not differ significantly between the diabetic and nondiabetic rats. Compared with control animals without MI, the atrial ANP/beta-actin mRNA ratio in rats with MI was increased to 195% in diabetic animals and 213% in nondiabetic animals. In the left ventricle, however, the ANP/beta-actin mRNA ratio in diabetic animals with MI was increased to only 131% compared with control animals, whereas the corresponding increase in nondiabetic animals was 240% (p<0.05). Thus, the modulation of ANP mRNA expression after MI was impaired in the left ventricle, but not in the atria, of diabetic rats. A reduced myocardial expression of ANP could increase the morbidity and mortality associated with cardiovascular disorders in patients with diabetes.

摘要

我们评估了心肌梗死（MI）对链脲佐菌素诱导的糖尿病大鼠血流动力学及心房利钠肽（ANP）mRNA表达的影响。链脲佐菌素注射8周后，对糖尿病大鼠和年龄匹配的非糖尿病对照大鼠进行冠状动脉结扎。一周后，糖尿病大鼠和非糖尿病大鼠的左心室舒张末期压力、收缩压、梗死面积及血清ANP水平无显著差异。与未发生MI的对照动物相比，发生MI的糖尿病大鼠心房ANP/β-肌动蛋白mRNA比值增至195%，非糖尿病大鼠增至213%。然而，在左心室，发生MI的糖尿病动物ANP/β-肌动蛋白mRNA比值仅增至131%，而对照动物为240%（p<0.05）。因此，MI后糖尿病大鼠左心室而非心房的ANP mRNA表达调节受损。ANP心肌表达降低可能会增加糖尿病患者心血管疾病相关的发病率和死亡率。