Saito Y, Nakao K, Arai H, Nishimura K, Takemura G, Fujiwara H, Sugawara A, Yamada T, Itoh H, Makoyama M
Department of Medicine, Kyoto University School of Medicine, Japan.
J Cardiovasc Pharmacol. 1989;13 Suppl 6:S1-4.
Using Northern blot analysis and radioimmunoassay, we measured atrial natriuretic polypeptide (ANP) messenger RNA and ANP levels in the ventricle in patients with old myocardial infarction and investigated the relationship between ventricular ANP synthesis and hemodynamic parameters. Levels of ANP messenger RNA and ANP were markedly increased in the left ventricular aneurysm, and a positive correlation was observed between the ANP level in the left ventricular aneurysm and pulmonary capillary wedge pressure (r = 0.85, p less than 0.05). These findings indicate that ANP synthesis in the ventricle is increased in accordance with the severity of congestive heart failure.
我们运用Northern印迹分析和放射免疫测定法，检测了陈旧性心肌梗死患者心室中的心房利钠多肽（ANP）信使核糖核酸及ANP水平，并研究了心室ANP合成与血流动力学参数之间的关系。左心室室壁瘤中ANP信使核糖核酸及ANP水平显著升高，且左心室室壁瘤中的ANP水平与肺毛细血管楔压之间呈正相关（r = 0.85，p < 0.05）。这些研究结果表明，心室中ANP的合成随着充血性心力衰竭的严重程度而增加。
