Kanda T, Nakano M, Arai M, Yamamoto A, Suzuki T, Murata K
2nd Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
Exp Clin Endocrinol. 1993;101(3):173-7. doi: 10.1055/s-0029-1211226.
The atrial natriuretic factor (ANF) messenger RNA (mRNA) content was determined in a rat model of acute myocardial infarction. Non-infarcted tissue of left and right ventricles were examined soon after ligation of the left descending anterior coronary artery. In the left ventricles, ANF mRNA/alpha-actin mRNA ratio increased to reach a maximum on day 7 and was sustained while in the right ventricle, the maximum was reached on day 1. The plasma ANF was significantly (p < 0.01) elevated from days 1 to 28 after coronary ligation. The primary compensatory response of ANF within the first 7 days may be attributed not only its synthesis in the left ventricle but also to its generation in the right ventricle in acute heart failure.
