Bohlke K, Cramer D W, Trichopoulos D, Mantzoros C S
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Epidemiology. 1998 Sep;9(5):570-3.
We evaluated the association of plasma insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) with risk of breast cancer in a study of 94 cases of premenopausal ductal carcinoma in situ and 76 controls. Compared with women in the lowest tertile of IGF-I, women in the upper two tertiles of IGF-I had an elevated risk for ductal carcinoma in situ. Conversely, compared with women in the lowest tertile of IGFBP-3, women in the upper two tertiles of IGFBP-3 had a decreased risk for ductal carcinoma in situ. After grouping women on the basis of both IGF-I and IGFBP-3, women in the highest two tertiles of IGF-I and the lowest tertile of IGFBP-3 were at notably higher risk than women in the lowest tertile of IGF-I and the highest two tertiles of IGFBP-3 (odds ratio = 3.7; 95% confidence interval = 1.1-12.2). We conclude that the combination of high IGF-I and low IGFBP-3 may increase the risk of premenopausal ductal carcinoma in situ.
在一项针对94例绝经前原位导管癌患者和76名对照者的研究中，我们评估了血浆胰岛素样生长因子-I（IGF-I）和IGF结合蛋白-3（IGFBP-3）与乳腺癌风险之间的关联。与IGF-I处于最低三分位数的女性相比，IGF-I处于最高两个三分位数的女性原位导管癌风险升高。相反，与IGFBP-3处于最低三分位数的女性相比，IGFBP-3处于最高两个三分位数的女性原位导管癌风险降低。在根据IGF-I和IGFBP-3对女性进行分组后，IGF-I处于最高两个三分位数且IGFBP-3处于最低三分位数的女性，其风险显著高于IGF-I处于最低三分位数且IGFBP-3处于最高两个三分位数的女性（比值比=3.7；95%置信区间=1.1-12.2）。我们得出结论，高IGF-I和低IGFBP-3的组合可能会增加绝经前原位导管癌的风险。
