Arys A, Philippart C, Dourov N, He Y, Le Q T, Pireaux J J
Université Libre de Bruxelles, Laboratoire dAnatomie Pathologique et de Microscopie Electronique, Faculté de Médecine-Erasme, Brussels, Belgium.
J Biomed Mater Res. 1998 Fall;43(3):300-12. doi: 10.1002/(sici)1097-4636(199823)43:3<300::aid-jbm11>3.0.co;2-j.
A multitechnique approach has been used to characterize the surface of nonosseointegrated titanium implants and the surrounding biological tissues. Five pure titanium dental implants were used as reference, and 25 removed implants were studied. Surface and in-depth chemical compositions of the implants (from a total of 16 patients) were investigated by X-ray photoelectron spectroscopy (XPS). Histological slides of the surrounding tissues were examined by light microscopy, XPS, and electron microprobe analysis. None of the failed implants presented the regular surface composition and depth profile of the TiO2 overlayer; foreign elements (Ca, Na, P, Si, Cl, Zn, Pb, and Al) were observed on some implants. Fibrosis, lymphocytic and plasmocytic infiltrates, and granulomatous lesions were detected in the surrounding tissues. XPS and electron microprobe analysis indicated the presence of Zn, Fe, Sn, and Ti in the tissues. As a possible scenario for implant failure, we propose and discuss a oxidoreduction mechanism, leading to a partial dissolution or the complete dissociation of the protective titanium dioxide overlayer and to ion diffusion through the surrounding tissues.
已采用多种技术方法来表征未骨整合钛植入物的表面及周围生物组织。以5颗纯钛牙种植体作为对照，对25颗取出的种植体进行了研究。通过X射线光电子能谱（XPS）研究了植入物（共16例患者）的表面和深度化学成分。通过光学显微镜、XPS和电子微探针分析对周围组织的组织学切片进行了检查。所有失败的种植体均未呈现出TiO₂覆盖层的规则表面组成和深度分布；在一些种植体上观察到了外来元素（钙、钠、磷、硅、氯、锌、铅和铝）。在周围组织中检测到纤维化、淋巴细胞和浆细胞浸润以及肉芽肿性病变。XPS和电子微探针分析表明组织中存在锌、铁、锡和钛。作为种植体失败的一种可能情况，我们提出并讨论了一种氧化还原机制，该机制会导致保护性二氧化钛覆盖层部分溶解或完全解离，并导致离子通过周围组织扩散。
