熊去氧胆酸（UDCA）治疗胎儿成红细胞增多症中的梗阻性黄疸：一例报告

Treatment of obstructive jaundice in erythroblastosis fetalis with ursodeoxycholic acid (UDCA): a case report.

作者信息

Perez E M, Cooper T R, Moise A A, Ferry G D, Weisman L E

机构信息

Department of Pediatrics, Baylor College of Medicine, Houston, Tex 77030, USA.

出版信息

J Perinatol. 1998 Jul-Aug;18(4):317-9.

PMID:9730206

Abstract

OBJECTIVE

To report a significant improvement of direct hyperbilirubinemia values, in an infant with cholestasis secondary to erythroblastosis fetalis, after treatment with ursodeoxycholic acid (UDCA).

STUDY DESIGN

Case report.

RESULTS

A full term infant, with total and direct bilirubin values of 26 mg/dl (445 micromol/l) and 24.5 mg/dl (419 micromol/l), respectively, on the third day of life, had total and direct bilirubin values of 8.2 mg/dl (140 micromol/l) and 6.9 mg/dl (118 micromol/l), respectively, after 2 days of treatment with UDCA. Because the natural course of this cholestasis takes several weeks to resolve, the observed improvement is highly suggestive of a direct effect of UDCA on the disease course.

CONCLUSION

This treatment may add a new therapeutic option to the limited measures available for this condition, although further studies regarding safety and its mechanism of action are needed before it can be routinely recommended.

摘要

目的

报告一例因胎儿成红细胞增多症继发胆汁淤积的婴儿，在接受熊去氧胆酸（UDCA）治疗后直接胆红素值有显著改善。

研究设计

病例报告。

结果

一名足月儿，出生第三天时总胆红素和直接胆红素值分别为26mg/dl（445微摩尔/升）和24.5mg/dl（419微摩尔/升），在接受UDCA治疗2天后，总胆红素和直接胆红素值分别为8.2mg/dl（140微摩尔/升）和6.9mg/dl（118微摩尔/升）。由于这种胆汁淤积的自然病程需要数周才能缓解，观察到的改善强烈提示UDCA对病程有直接影响。