Combinatorial synthesis and screening of a chemical library of 1,4-dihydropyridine calcium channel blockers.
作者信息
Gordeev M F, Patel D V, England B P, Jonnalagadda S, Combs J D, Gordon E M
机构信息
Affymix Research Institute, Santa Clara, CA 95051, USA.
出版信息
Bioorg Med Chem. 1998 Jul;6(7):883-9. doi: 10.1016/s0968-0896(98)00048-0.
PMID:9730224
Abstract
Solid-phase synthesis of a 300-member pharmacophore library of 1,4-dihydropyridines from keto ester, diketone and aldehyde building blocks on a cleavable amine polymeric support is described. Screening and serial deconvolution of the combinatorial library has resulted in identification of known and new potent calcium channel blockers.
摘要
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