Radioligand binding studies on some dihydropyridine analogues as probes of the dihydropyridine receptor.

The affinity of two compounds, closely related to 1,4-dihydropyridines, was determined in competition binding experiments using canine cerebral cortex membranes and [3H]nitrendipine as a radioligand. Some aspects of structure-affinity relationships are discussed in relation to existing models of the dihydropyridine binding site.