Novel dithiocarbamate carbapenems with anti-MRSA activity.
作者信息
Ohtake N, Imamura H, Jona H, Kiyonaga H, Shimizu A, Moriya M, Sato H, Nakano M, Ushijima R, Nakagawa S
机构信息
Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Japan.
出版信息
Bioorg Med Chem. 1998 Jul;6(7):1089-101. doi: 10.1016/s0968-0896(98)00069-8.
PMID:9730246
Abstract
A new series of 1beta-methyl carbapenems, in which a disubstituted-aminothiocarbonylthio moiety was attached to the C-2 position of the carbapenem nucleus, were prepared and evaluated for anti-MRSA activity. These derivatives showed good in vitro antibacterial activity against high-level MRSA, and the finding of good affinity for PBP-2' supported these results. Some of the compounds having favorable protein-binding affinity showed excellent in vivo anti-MRSA activity.
摘要
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