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头孢比普在耐甲氧西林和万古霉素中介金黄色葡萄球菌所致兔主动脉瓣心内膜炎模型中的评价。

Evaluation of ceftobiprole in a rabbit model of aortic valve endocarditis due to methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.

作者信息

Chambers Henry F

机构信息

Division of Infectious Diseases, San Francisco General Hospital, and University of California--San Francisco, Room 3400, Building 30, 1001 Potrero Ave., San Francisco, CA 94110, USA.

出版信息

Antimicrob Agents Chemother. 2005 Mar;49(3):884-8. doi: 10.1128/AAC.49.3.884-888.2005.

DOI:10.1128/AAC.49.3.884-888.2005
PMID:15728879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC549268/
Abstract

Ceftobiprole is a novel broad-spectrum cephalosporin that binds with high affinity to PBP 2a, the methicillin-resistance determinant of staphylococci, and is active against methicillin- and vancomycin-resistant Staphylococcus aureus. Ceftobiprole was compared to vancomycin in a rabbit model of methicillin-resistant S. aureus aortic valve endocarditis. Ceftobiprole and vancomycin were equally effective against endocarditis caused by methicillin-resistant S. aureus strain 76, whereas ceftobiprole was more effective than vancomycin against the vancomycin-intermediate S. aureus strain HIP5836. The activity of ceftobiprole against drug-resistant strains of S. aureus warrants its further clinical development.

摘要

头孢比普是一种新型广谱头孢菌素，它与葡萄球菌的耐甲氧西林决定因子PBP 2a具有高亲和力结合，并且对耐甲氧西林和耐万古霉素的金黄色葡萄球菌具有活性。在耐甲氧西林金黄色葡萄球菌主动脉瓣心内膜炎的兔模型中，对头孢比普和万古霉素进行了比较。头孢比普和万古霉素对耐甲氧西林金黄色葡萄球菌菌株76引起的心内膜炎同样有效，而头孢比普对万古霉素中介的金黄色葡萄球菌菌株HIP5836比万古霉素更有效。头孢比普对金黄色葡萄球菌耐药菌株的活性值得进一步进行临床开发。

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本文引用的文献

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In vitro activities of a novel cephalosporin, CB-181963 (CAB-175), against methicillin-susceptible or -resistant Staphylococcus aureus and glycopeptide-intermediate susceptible staphylococci.新型头孢菌素CB-181963（CAB-175）对甲氧西林敏感或耐药金黄色葡萄球菌以及糖肽类中介敏感葡萄球菌的体外活性
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Multiple-dose pharmacokinetics and safety of a novel broad-spectrum cephalosporin (BAL5788) in healthy volunteers.新型广谱头孢菌素（BAL5788）在健康志愿者中的多剂量药代动力学及安全性研究
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Single-dose pharmacokinetics and safety of a novel broad-spectrum cephalosporin (BAL5788) in healthy volunteers.新型广谱头孢菌素（BAL5788）在健康志愿者中的单剂量药代动力学及安全性
Antimicrob Agents Chemother. 2004 Jul;48(7):2570-5. doi: 10.1128/AAC.48.7.2570-2575.2004.
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Efficacy of BAL5788, a prodrug of cephalosporin BAL9141, in a mouse model of acute pneumococcal pneumonia.头孢菌素BAL9141的前体药物BAL5788在急性肺炎球菌肺炎小鼠模型中的疗效。
Antimicrob Agents Chemother. 2004 Apr;48(4):1105-11. doi: 10.1128/AAC.48.4.1105-1111.2004.
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PBP 2a mutations producing very-high-level resistance to beta-lactams.产生对β-内酰胺类抗生素极高水平耐药性的PBP 2a突变。
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Antimicrob Agents Chemother. 2002 Jan;46(1):171-7. doi: 10.1128/AAC.46.1.171-177.2002.