Tohda Y, Muraki M, Iwanaga T, Kubo H, Fukuoka M, Nakajima S
Fourth Department of Internal Medicine, Kinki University School of Medicine, Osakasayama, Osaka, Japan.
Int J Immunopharmacol. 1998 Apr-May;20(4-5):173-81. doi: 10.1016/s0192-0561(98)00026-5.
It was recently reported that theophylline has an anti-inflammatory and bronchodilating effect on bronchial asthma. Accordingly, to examine the anti-inflammatory effect of theophylline on asthma, especially its effect on eosinophil activation, a sustained-release theophylline preparation (Theolong) was administered (daily dose: 400 mg) to 18 patients with mild to moderate bronchial asthma. This was done in order to study the preparation's effects on lung function, blood and sputum eosinophils and ECP four weeks pre- and post-administration. Lung function was determined by spirometry and sputum by induced sputum. Blood and sputum ECP levels were determined using an ECP RIA kit. In lung function, there were no differences in vital capacity (VC) or in forced expiratory volume 1 s (FEV 1.0) pre- and post-administration. There were also no differences in the number of blood and sputum eosinophils, but serum and sputum ECP levels decreased. Theophylline is thus expected to exert an inhibitory effect on eosinophil activation and it is suggested as an effective therapeutic drug for bronchial asthma.
最近有报道称，茶碱对支气管哮喘具有抗炎和支气管扩张作用。因此，为了研究茶碱对哮喘的抗炎作用，尤其是其对嗜酸性粒细胞活化的影响，对18例轻至中度支气管哮喘患者给予了缓释茶碱制剂（Theolong）（每日剂量：400mg）。这样做是为了研究该制剂在给药前后四周对肺功能、血液和痰液嗜酸性粒细胞以及嗜酸性粒细胞阳离子蛋白（ECP）的影响。肺功能通过肺活量测定法测定，痰液通过诱导痰液法获取。血液和痰液ECP水平使用ECP放射免疫分析试剂盒测定。在肺功能方面，给药前后的肺活量（VC）或第1秒用力呼气量（FEV1.0）没有差异。血液和痰液嗜酸性粒细胞数量也没有差异，但血清和痰液ECP水平有所下降。因此，茶碱有望对嗜酸性粒细胞活化发挥抑制作用，并被认为是支气管哮喘的一种有效治疗药物。
