Qumsiyeh M B
Duke University Medical Center, Durham, North Carolina 27710, USA.
J Matern Fetal Med. 1998 Jul-Aug;7(4):210-2. doi: 10.1002/(SICI)1520-6661(199807/08)7:4<210::AID-MFM10>3.0.CO;2-H.
Data are presented confirming that placental chromosome abnormalities are more important than fetal chromosome abnormalities in determining fetal loss. Improved methodologies for studying chromosome abnormalities in spontaneous abortion (SAB) are presented that include results for 141 cases (gestational ages 6-24 weeks) with karyotypic study on placental as well as fetal tissue. Experience in two laboratories gave a success rate of >90% of specimens with identifiable placental tissues, an average turnaround time of 10 days for those that produced chromosome results, male-to-female ratio of >50% (indicating no impact of maternal cell contamination), and 30% of cases had chromosome abnormalities. More significantly, two cases (5% of all abnormal cases) showed an abnormal karyotype limited to the placenta. This illustrates the need to examine the placenta in cases of SAB and the importance of technical issues in laboratory studies.
所呈现的数据证实，在决定胎儿丢失方面，胎盘染色体异常比胎儿染色体异常更为重要。本文介绍了用于研究自然流产（SAB）中染色体异常的改进方法，其中包括对141例病例（孕周6 - 24周）胎盘及胎儿组织进行核型分析的结果。两个实验室的经验表明，可识别胎盘组织的标本成功率超过90%，得出染色体结果的标本平均周转时间为10天，男女比例超过50%（表明无母体细胞污染影响），且30%的病例存在染色体异常。更显著的是，有两例（占所有异常病例的5%）显示核型异常仅限于胎盘。这说明了在SAB病例中检查胎盘的必要性以及实验室研究中技术问题的重要性。
