Iimori H, Kawamura N, Wenner M, Murakami M, Yamamoto H
Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
Neuroimmunomodulation. 1998 Sep-Oct;5(5):221-5. doi: 10.1159/000026341.
Electrical stimulation of the lateral hypothalamus (LH) in rats increased splenic natural killer (NK) cell activity, whereas electrical ablation of the LH decreased it. However, the percentage of NK cells, as detected by the anti-NKR-P1 monoclonal antibody, in the spleen did not change significantly. These results suggest that the LH does not modulate the splenic NK cell activity by increasing the NK cell number but by increasing the intrinsic NK cell activity itself.
对大鼠下丘脑外侧区（LH）进行电刺激会增加脾脏自然杀伤（NK）细胞的活性，而对LH进行电损毁则会使其活性降低。然而，用抗NKR-P1单克隆抗体检测到的脾脏中NK细胞的百分比并未发生显著变化。这些结果表明，LH并非通过增加NK细胞数量来调节脾脏NK细胞的活性，而是通过增强NK细胞自身的内在活性来实现的。
