Genovesi-Ebert F, Di Bartolo E, Lepri A, Poggi V, Romani A, Nardi M
Neuroscience Department, Institute of Opthalmology, Pisa University, Pisa, Italy.
Ophthalmologica. 1998;212 Suppl 1:101-3. doi: 10.1159/000055442.
Twenty-four patients (47 eyes) affected by Graves' disease were enrolled to evaluate the role of standardized echography, pattern electroretinogram (P-ERG), visual evoked potentials (P-VEPs) and automated perimetry in the early diagnosis of the compressive optic neuropathy (CON). The P-ERG amplitude reduction was the most sensitive parameter to demonstrate an early impairment of the optic nerve (ON) function. We found a significant negative correlation between the ON diameter and the P-ERG amplitude. VEPs responses were also altered, but their ability in detecting an early ON damage was less sensitive and specific than P-ERG. The visual field damage was often aspecific and delayed with respect to electrophysiological alterations.
24例（47只眼）患有格雷夫斯病的患者被纳入研究，以评估标准化超声检查、图形视网膜电图（P-ERG）、视觉诱发电位（P-VEP）和自动视野计在压迫性视神经病变（CON）早期诊断中的作用。P-ERG振幅降低是显示视神经（ON）功能早期损害的最敏感参数。我们发现ON直径与P-ERG振幅之间存在显著负相关。VEP反应也有改变，但其检测ON早期损伤的能力不如P-ERG敏感和特异。视野损害相对于电生理改变通常是非特异性的且出现较晚。
