Spadea L, Bianco G, Dragani T, Balestrazzi E
University of L'Aquila, Department of Ophthalmology, Italy.
Graefes Arch Clin Exp Ophthalmol. 1997 Aug;235(8):501-5. doi: 10.1007/BF00947007.
In Graves' disease the optic neuropathy (ON) is due to direct compression of the nerve and/or of its blood supply. The aim of the present study was to detect early changes in the visual functions of patients affected by ophthalmic Graves' disease (OGD) by using electrophysiological tests (P-VEP and PERG).
We studied 50 OGD patients who were in a range between class 2 and class 5 according to the Donaldson-American Thyroid Association classification, i.e. had no evident ON and normal visual acuity. We recorded transient reversal PERG and P-VEP in response to the stimulation of one eye at three spatial frequencies (2.2, 1.1 and 0.5 c/d).
Our results showed a statistically significant reduction in PERG amplitude in class 5, while the P-VEP amplitude was already reduced in class 2.
The electrofunctional tests were useful to detect small changes in the visual function of patients affected by initial stages of OGD. Therefore, P-VEP and PERG recordings appear to be a useful tool for early diagnosis of the optic nerve involvement in Graves' disease.
在格雷夫斯病中，视神经病变（ON）是由于神经及其血供受到直接压迫所致。本研究的目的是通过电生理测试（图形视觉诱发电位P-VEP和图形视网膜电图PERG）检测患有眼部格雷夫斯病（OGD）患者视觉功能的早期变化。
我们研究了50例根据唐纳森-美国甲状腺协会分类处于2级至5级的OGD患者，即没有明显的ON且视力正常。我们记录了在三个空间频率（2.2、1.1和0.5周/度）下对一只眼睛进行刺激时的瞬态反转PERG和P-VEP。
我们的结果显示，5级患者的PERG波幅有统计学意义的降低，而2级患者的P-VEP波幅已经降低。
电功能测试有助于检测OGD初始阶段患者视觉功能的微小变化。因此，P-VEP和PERG记录似乎是早期诊断格雷夫斯病视神经受累的有用工具。
